OUR PUBLICATIONS
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Woods S, Basco J, Clemens S., Effects of iron-deficient diet on sleep onset and spinal reflexes in a rodent model of Restless Legs Syndrome. 2023, Frontiers in Neurology, https://doi.org/10.3389/fneur.2023.1160028
Silvani A, Ghorayeb I, Manconi M, Li Y, Clemens S., Putative animal models of Restless Legs Syndrome: a systematic review and evaluation of their face and construct validity. Neurotherapeutics, 2023, 20(1):154-178
Clemens S. (2023). Restless Legs Syndrome, in: Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders (2nd edition), Zigmond M.J., Clayton A.W., Chesselet, M.F., and Weston C. (eds), Elsevier
Clemens S., D3 Receptors and Restless Legs Syndrome. 2023, Current Topics in Behavioral Neuroscience, 229-249
Salminen AV, Clemens S, García-Borreguero D, Ghorayeb I, Li Y, Manconi M, Ondo W, Rye D, Siegel JM, Silvani A, Winkelman JW, Allen RP, Ferré S., Consensus guidelines on the construct validity of rodent models of restless legs syndrome. 2022, Disease Model Mechanisms, 15(8) 1-12
Silber MH, Buchfuhrer MJ, Earley CJ, Koo BB, Manconi M, Winkelman JW., The Management of Restless Legs Syndrome: An Updated Algorithm. Mayo Clin Proc. 2021
Salminen AV, Silvani A, Allen RP, Clemens S, Garcia-Borreguero D, Ghorayeb I, Ferré S, Li Y, Ondo W, Picchietti DL, Rye D, Siegel JM, Winkelman JW, Manconi M., Consensus Guidelines on Rodent Models of Restless Legs Syndrome. Mov Disord. 2021
Lyu S, Doroodchi A, Xing H, Sheng Y, DeAndrade MP, Yang Y, Johnson TL, Clemens S, Yokoi F, Miller MA, Xiao R, Li Y., BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome. Brain Struct Funct. 2020
Clemens S., Lallemand P. 2020, Treatment and management of augmentation in Restless Legs Syndrome, US Patent 10,751,327
Clemens S, Ghorayeb I., D3 and D1 receptors: The Yin and Yang in the treatment of restless legs syndrome with dopaminergics. Adv Pharmacol. 2019
Trenkwalder C, Allen R, Högl B, Clemens S, Patton S, Schormair B, Winkelmann J., Comorbidities, treatment, and pathophysiology in restless legs syndrome. Lancet Neurol. 2018
Meneely S, Dinkins ML, Kassai M, Lyu S, Liu Y, Lin CT, Brewer K, Li Y, Clemens S., Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome. Front Behav Neurosci. 2018
Dinkins ML, Lallemand P, Clemens S., Long-term treatment with dopamine D3 receptor agonists induces a behavioral switch that can be rescued by blocking the dopamine D1 receptor. Sleep Med. 2017
Ferré S, Quiroz C, Guitart X, Rea W, Seyedian A, Moreno E, Casadó-Anguera V, Díaz-Ríos M, Casadó V, Clemens S, Allen RP, Earley CJ, García-Borreguero D., Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome. Front Neurosci. 2017
Earley CJ, Uhl GR, Clemens S, Ferré S., Connectome and molecular pharmacological differences in the dopaminergic system in restless legs syndrome (RLS): plastic changes and neuroadaptations that may contribute to augmentation. Sleep Med. 2017
Manconi M, Ferri R, Zucconi M, Clemens S, Giarolli L, Bottasini V, Ferini-Strambi L., Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome. Neurology. 2011
Thorpe AJ, Clair A, Hochman S, Clemens S., Possible sites of therapeutic action in restless legs syndrome: focus on dopamine and α2δ ligands. Eur Neurol. 2011
Manconi M, Ferri R, Zucconi M, Clemens S, Rundo F, Oldani A, Ferini-Strambi L., Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep. Sleep Med. 2011
Clemens S, Rye D, Hochman S., Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology. 2006
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Rodgers HM, Patton R, Yow J, Zeczycki TN, Kew K, Clemens S, Brewer KL. 2022, Morphine Resistance in Spinal Cord Injury-Related Neuropathic Pain in Rats is Associated With Alterations in Dopamine and Dopamine-Related Metabolomics. J Pain. 2022
Brewer K, Clemens S, Methods and compositions for maintaining opioid efficacy in the treatment of pain. 2021, US Patent 11,202,777
Rodgers HM, Lim SA, Yow J, Dinkins ML, Patton R, Clemens S, Brewer KL., Dopamine D1 or D3 receptor modulators prevent morphine tolerance and reduce opioid withdrawal symptoms. 2020, Pharmacology Biochemistry and Behavior, 194:172935
Rodgers HM, Yow J, Evans E, Clemens S, Brewer KL. 2019, Dopamine D1 and D3 receptor modulators restore morphine analgesia and prevent opioid preference in a model of neuropathic pain. Neuroscience, 406:376-388
Samir S, Yllanes AP, Lallemand P, Brewer KL, Clemens S., Morphine responsiveness to thermal pain stimuli is aging-associated and mediated by dopamine D1 and D3 receptor interactions. Neuroscience. 2017
Brewer KL, Baran CA, Whitfield BR, Jensen AM, Clemens S., Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord. Front Neural Circuits. 2014
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Johnson TL, Clemens S., Differential dopamine modulation of spinal reflex amplitudes is associated with the presence or absence of the autonomic nervous system. Neurosci Lett. 2021
Rivera-Oliver M, Moreno E, Álvarez-Bagnarol Y, Ayala-Santiago C, Cruz-Reyes N, Molina-Castro GC, Clemens S, Canela EI, Ferré S, Casadó V, Díaz-Ríos M., Adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron. Mol Neurobiol. 2019
Keeler BE, Lallemand P, Patel MM, de Castro Brás LE, Clemens S., Opposing aging-related shift of excitatory dopamine D1 and inhibitory D3 receptor protein expression in striatum and spinal cord. J Neurophysiol. 2016
Sharples SA, Humphreys JM, Jensen AM, Dhoopar S, Delaloye N, Clemens S, Whelan PJ., Dopaminergic modulation of locomotor network activity in the neonatal mouse spinal cord. J Neurophysiol. 2015
Keeler BE, Baran CA, Brewer KL, Clemens S., Increased excitability of spinal pain reflexes and altered frequency-dependent modulation in the dopamine D3-receptor knockout mouse. Exp Neurol. 2012
Clemens S, Belin-Rauscent A, Simmers J, Combes D., Opposing modulatory effects of D1- and D2-like receptor activation on a spinal central pattern generator. J Neurophysiol. 2012
Zhu H, Clemens S, Sawchuk M, Hochman S., Unaltered D1, D2, D4, and D5 dopamine receptor mRNA expression and distribution in the spinal cord of the D3 receptor knockout mouse. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2008
Zhu H, Clemens S, Sawchuk M, Hochman S., Expression and distribution of all dopamine receptor subtypes (D(1)-D(5)) in the mouse lumbar spinal cord: a real-time polymerase chain reaction and non-autoradiographic in situ hybridization study. Neuroscience. 2007
Clemens S, Sawchuk MA, Hochman S., Reversal of the circadian expression of tyrosine-hydroxylase but not nitric oxide synthase levels in the spinal cord of dopamine D3 receptor knockout mice. Neuroscience. 2005
Clemens S, Hochman S., Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci. 2004
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Kisling A, Byrne S, Parekh RU, Melit-Thomas D, de Castro Brás LE, Lust RM, Clemens S, Sriramula S, Katwa LC., Loss of Function in Dopamine D3 Receptor Attenuates Left Ventricular Cardiac Fibroblast Migration and Proliferation in vitro. Front Cardiovasc Med. 2021
McDonnell J, Murray NP, Ahn S, Clemens S, Everhart E, Mizelle JC., Examination and comparison of theta band connectivity in left-and right-hand dominant individuals throughout a motor skill acquisition. Symmetry. 2021
Gaweda G, Iyer RP, Shaver PR, Grilo GA, Dinkins ML, Stoffel HJ, Clemens S, de Castro Brás LE., Dopamine receptor D3 agonist (Pramipexole) reduces morphine-induced cardiac fibrosis. Biochem Biophys Res Commun. 2020
Johnson TL, Tulis DA, Keeler BE, Virag JA, Lust RM, Clemens S., The dopamine D3 receptor knockout mouse mimics aging-related changes in autonomic function and cardiac fibrosis. PLoS One. 2013
Wu D, Raafat A, Pak E, Clemens S, Murashov AK., Dicer-microRNA pathway is critical for peripheral nerve regeneration and functional recovery in vivo and regenerative axonogenesis in vitro. Exp Neurol. 2012
Clemens S, Calin-Jageman R, Sakurai A, Katz PS., Altering cAMP levels within a central pattern generator modifies or disrupts rhythmic motor output. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2007
Katz PS, Sakurai A, Clemens S, Davis D., Cycle period of a network oscillator is independent of membrane potential and spiking activity in individual central pattern generator neurons. J Neurophysiol. 2004
Clemens S, Katz PS., G protein signaling in a neuronal network is necessary for rhythmic motor pattern production. J Neurophysiol. 2003
Clemens S, Massabuau JC, Meyrand P, Simmers J., A modulatory role for oxygen in shaping rhythmic motor output patterns of neuronal networks. Respir Physiol. 2001
Katz PS, Clemens S., Biochemical networks in nervous systems: expanding neuronal information capacity beyond voltage signals. Trends Neurosci. 2001
Clemens S, Katz PS., Identified serotonergic neurons in the Tritonia swim CPG activate both ionotropic and metabotropic receptors. J Neurophysiol. 2001
Clemens S, Massabuau JC, Meyrand P, Simmers J., Changes in motor network expression related to moulting behaviour in lobster: role of moult-induced deep hypoxia. J Exp Biol. 1999
Clemens S, Meyrand P, Simmers J., Feeding-induced changes in temporal patterning of muscle activity in the lobster stomatogastric system. Neurosci Lett. 1998
Clemens S, Massabuau JC, Legeay A, Meyrand P, Simmers J., In vivo modulation of interacting central pattern generators in lobster stomatogastric ganglion: influence of feeding and partial pressure of oxygen. J Neurosci. 1998
Clemens S, Combes D, Meyrand P, Simmers J., Long-term expression of two interacting motor pattern-generating networks in the stomatogastric system of freely behaving lobster. J Neurophysiol. 1998